Conference Call

We hosted our big (around 400+ people) pharma-conference & exhibition yesterday, and that’s the most nerve-wracking day of my year.

This edition’s Big Surprise occurred shortly before the first presentation, when our marketing assistant informed me that, while he did bring down the PC laptop that we use for the presentations, he forgot to bring the power supply for it. So I had to go through our exhibit hall, check out which of the 130 vendors happened to be using ThinkPads, and cajole use of their power-cords during the day.

We have 5 more presentations going on this morning, but the exhibition ended yesterday, so I’m not entirely sure how I’m going to manage to keep that laptop powered up.

From the Editor: Idiot’s Alchemy

(Sorry I haven’t written much lately, dear readers. I’ve been awfully busy at work, and pretty burned-out by the time I’m home. But I’ll wrap up most of it today, and then Amy & I are off on a mini-vacation. More later! Meanwhile, here’s this issue’s From the Editor column.)

Idiots’ Alchemy

Making money out of nothing at all

In keeping with last issue’s Hollywood-themed editorial, I’ve decided to write a sequel! This month, we move from blockbusters to bombs. In Hudson Hawk, my favorite terrible movie, the archvillains plot to demolish the world banking system by flooding it with alchemically produced gold. At least, I think that’s the plot. It’s tough to follow, what with the implausible action sequences, candy-bar code-named CIA operatives (with David Caruso as Kit Kat!), a nun-as-love-interest, and musical numbers featuring Danny Aiello and Bruce Willis.

The action revolves around Darwin and Minerva Mayflower — campily played by Richard E. Grant and Sandra Bernhard — and their reconstruction of a lead-to-gold machine designed by Leonardo Da Vinci. Says Minerva, “After a couple of years of steady production, we’ll flood the market with so much gold that gold itself — the foundation of all finance — will lose its meaning.”

Of course, Nixon ended the gold standard 20 years before Hudson Hawk came out, rendering the Mayflowers’ plot moot. And yet it’s also eerily prescient. After all, gold qua gold doesn’t mean so much anymore, not as a “foundation of all finance.” Now it’s just another commodity in which to invest.

What we’re left with is money itself. Funnily enough, while we’re free of gold, we haven’t gotten over alchemy. Instead of la machina oro, we have “quant funds,” those hedge funds that employ statistical models so sophisticated that they can “find winning trade strategies,” as the Wall Street Journal puts it. From equations to money, like magic!

Turns out one of these winning trade strategies was investing in financial instruments that were based heavily on subprime mortgages (that is, the practice of giving large loans to people who have poor credit). Some of these sophisticated investing models managed to underestimate the risk of — repeat after me — giving large loans to people who have poor credit.

Finding themselves pummeled by margin calls and investor redemption requests (that is, investors trying to get their money out of these fabulous funds before it all disappeared), some funds required massive bailouts from their parent institutions. Outspoken financial personality Jim Cramer made the YouTube rounds by ranting about how the government needs to step in with an interest reduction, ostensibly to save the homes of subprime mortgage holders, but also to save the jobs of hedge fund managers.

Evaluating risk — the true foundation of finance — lost its meaning. For a while.

So how does this tie into pharma? Well, first there’s the direct impact of this credit shakeup on private equity firms. Many of these groups employ leveraging techniques to (partially) fund acquisitions of public companies. We’ve seen several contract manufacturers acquired by PE firms this year, but with money less easy to borrow, will further acquisitions be back-burnered?

But the other pharma tie-in is potentially more damaging, and that’s the bizarre talk about a new round of mega-mergers in the drug industry. First we heard rumors of Novartis’ interest in buying Bayer, and then an analyst floated the idea that Pfizer should acquire Wyeth.

Regarding the former, you can learn more with Derek Lowe’s In the Pipeline excerpt on page 40. As far as the latter? Well, I think the argument for a Pfizer/Wyeth hookup is far more flawed than that which guided Pfizer’s Warner-Lambert and Pharmacia buys earlier this decade. In those instances, Pfizer could point to its co-marketing agreements for major drugs and show how 100% control of those products would lead to greater sales. You may recall that I disagreed with those moves, not that I take any joy in how that turned out.

Now? Pfizer’s key motivation (says our analyst) is the acquisition of Wyeth’s biologics program, which she compares to AstraZeneca’s MedImmune acquisition. Which cost more than a dozen times MedImmune’s earnings. In cash.

But I’m starting to think that the point of these rumors — and there’ll be more this year — isn’t to push for those particular mergers. Rather, it’s to incite any sort of big merger activity, because the banks that took a bath this summer need to boost their financing and underwriting businesses this fall.

Let’s hope the new CFOs are smart enough to keep the industry’s recent merger history in mind. Otherwise, we could be looking more upheaval. Or, as Darwin Mayflower put it in Hudson Hawk, “History, tradition, culture: these are not concepts! These are trophies I keep in my den as paperweights! The chaos we cause the world with this machine will be our final masterpiece! Go, team, go!”

It also fixes your schwerve

Sure, I get plenty of headaches at work, but there’s also fun to be had. You just have to know where to look. For instance, while checking out news releases this morning, I stumbled across a clinical-stage drug that’s described as a “minor groove binder.”

Physical Humor

I’m in my mid-30s and have a family history of high blood pressure, diabetes and heart disease, so I figure it’s best that I start getting some expert opinion on my health. I’m not diligent enough to see a doctor regularly, but I did manage to have my nowhere-near-annual physical this morning.

I had to fill out a general medical info form when I got to the office. Near the top of the form was a line for ‘Chief complaint,’ which I responded to with “high taxes.” I know I should’ve gone with “incivility on the internet,” but that’s what you get for writing in ink.

Anyway, the doctor was happy with pretty much everydarnthing. My LDL’s a little high, but it’s down 30 points from my last checkup in September 2005, so no statins for me! Blood pressure, heart-rate and EKG were also just fine. He even praised my moderate drinking, though he admitted that there wasn’t a ton of research on the benefits of gin.

I was actually a little worried about that EKG, given a family member’s recent episode of SVT, but the doctor assuaged my fears on that one. He mentioned that the EKG showed no basic signs of it and, “When you hit 50, we’ll do a stress test and all the other regular exams.”

“When I’m 50,” I said, “we’ll have nanobots to take care of that stuff.”

Then I thought, I’m gonna be 50?

Bear Stearns: Bare, Stern

This NYTimes article provides the most detailed account of a firing I’ve ever read in a paper. Warren J. Spector at Bear Stearns got the boot because his unit controlled the hedge funds that imploded a few weeks back. The first hint that it’s a weird article is the description of the firing:

Sitting behind his half moon desk on which stood computer terminals and a large metal-box lighter, Mr. Cayne broke the news to Mr. Spector that he wanted his resignation.

Seemed like a little more info than we needed. Then it began exploring the two men’s history with the game of bridge:

Indeed, with Mr. Spector’s own talent for bridge — he achieved the rank of life master at age 16 in 1974 — and his expertise in all varieties of bonds, it was widely assumed that Mr. Cayne would pass on the reins to Mr. Spector. (The two men’s devotion to bridge is highlighted by the fact that they both attended the North American bridge championship in Nashville late last July, at a time of increasing turmoil in the credit markets.)

But while bridge might have functioned as a bonding agent between Mr. Cayne and his predecessor, Alan C. Greenberg, it could not do the same for Mr. Spector — especially in the wake of the hedge fund meltdown at the firm’s asset management division.

Did I mention there’s too much detail?

In part this was a function of their sharply different personalities. Mr. Cayne is a raw, cigar-chomping man who embraces the scrappy, street-fighting ethos of the firm. Mr. Spector, who wears his thick head of hair longer than that of the standard banker, has more of suave, relaxed affect.

I guess the big question is: which guy’s the better bridge partner?

(Update: The WSJ article on Spector’s firing adds even more details, including the facts that he “wears black-rimmed glasses and maintains a trim physique”. . . and that he attended St. John’s College, where I got my master’s degree)

Getaway

Work is under control: the July/August issue landed on my desk yesterday, the Top Companies report’s website is live, our conference enrollment is rolling along, and our September issue looks like it’ll be a big one. So I’m taking a vacation day!

I’m heading down to Philly to visit a friend of mine (Drake, not Butch) for a while. No worries, dear readers: I’ll have my camera with me and will likely end up somewhere where I can take some neat pix. Maybe I’ll meander downtown in Philly or visit the suburbs near Swarthmore where I used to live. Or I could stop in Princeton on the way home and stop in at the campus art museum (and the Record Exchange, of course).