Gilgamesh and the Genome

It’s a blast from the past! Here’s a From the Editor page I wrote in March 2000, when I was a newbie on my pharma magazine! Enjoy

Nearly 50 years ago, Francis Watson and James Crick uncovered the double-helical structure of DNA. A little more than a century ago, the fragments of the epic poem of Gilgamesh were discovered in the ruins of ancient Mesopotamia. The tablets on which the poem were written date only a few hundred years after the invention of writing, a discovery that fundamentally changed human culture. The four-letter alphabet of DNA contains the possibilities of life in all its aspects. In both cases, scholars and scientists have spent years trying to decipher these strange languages.

Both of these sources, in a sense, address the same issue, albeit from opposite directions. Through the mapping of the human genome and the discoveries we shall make of the secrets of individual genes, we learn about the myriad individual components that create a gestalt of human life. Through gene therapy and other advances in biotechnology, we are told, man will someday overcome aging and possibly transcend death.

Through translating the story of Gilgamesh, we learn that man has always tried to circumvent death. The greatest king of his time (two-thirds divine, one-third man) travels to the limits of the underworld to learn how to overcome mortality. He learns that nothing is permanent. Upon returning to his kingdom of Uruk, all Gilgamesh can do is praise the strength of the city’s walls. Today, not one person in a million could identify Uruk on a map. Nor do those city walls stand. The first hero in literature faces the same limitations as a garbage man in the year 2000. Time passes and unmakes us all.

Scientists today question whether that process is necessary, and whether it can at least be slowed. The mission of translating the genetic language and making genes into a manipulable objects may accomplish Gilgamesh’s quest, 5000 years later.

About that fountainhead . . .

Neat interview at BusinessWeek with Joshua Prince-Ramus, the lead partner and owner of the New York branch of the Office of Metropolitan Architecture (OMA), the firm founded by Rem Koolhaas. It’s all about the rational process of designing “outrageous” buildings:

We believe in a hyper-rational process where you accept the constraints, conditions, and challenges of a project, and you attempt to engage them by going back to first principles. You don’t accept any convention. If someone says, “This is how you solve that problem,” you give them the bird. You just say, “I don’t want to hear it.” [. . .]

We’re seeing constraints as opportunities. It’s not like we’re getting around the constraints. We’re saying, “The project’s just the constraints.” If we can solve the constraints, that’s where the form will come, that’s where the beauty will come, that’s where the logic will come. And more likely than not, you can get it built, you can get it financed, you can get it on budget.

I find this stuff fascinating, but I have a different view on art than some of my friends. Read more.

Left out

Jane Galt has a nice post on the “message-vacuum” of the Democratic party. Here’s a piece:

Democrats have been blaming the candidates: the wooden Gore, the hapless Kerry. But it seems to me that the problem is that the fissures on the left are so deep that it takes a political genius like Clinton, who zeroed in on symbolic wedge issues with the daring precision of a World War II ace, to cover over them long enough to get elected. Neither Gore nor Kerry were particularly good candidates, to be sure, but it’s not like George Bush is a stunning rhetorician or a dazzling political strategist. His main skills (and weaknesses) lie in dogged determination and keen administrative abilities. Yet he defeated Al Gore, who should have walked all over Bush, given that he was running as the incumbent’s successor in the sunset year of America’s longest postwar economic expansion. Kerry couldn’t beat Bush even though the guy had been caught in bed with a naked economic recession, suffered through a subsequent jobless recovery, and got the country into an enormously expensive, and prolonged, conflict in Iraq. Is that really a problem of the candidates, or the party?

Read all about it.

Jacobean Mires

This week’s book is Gin: The Much Lamented Death of Madam Geneva, by Patrick Dillon. It’s about the British prohibition of gin in the 1730s, and has all sorts of parallels with the crack and crank “epidemics” of our time.

I came across a neat passage yesterday about the supporters of the deposed King James. Dillon discusses how, over the years, being a Jacobite is less about restoring James’ line to the throne and more about dissing the establishment (notwithstanding a minor bombing by Nixon & Killingbeck). As he writes:

Jacobitism was the fly in the ointment of Hanoverian stability; it was Britain’s loose cannon, its unfinished business. Nearly half a century after the Glorious Revolution, the Old Pretender still waited in Paris with his ridiculous court and his bogus ceremonial; whenever a French king wanted to annoy the English, he still had only to start talking about invasions and restorations. Back in England, the wounds of the Glorious Revolution had still not healed over.

All the same, Jacobitism had changed in the past few decades. The passage of half a century was bound to change something. Even in 1715, restoration had been a real possibility. There had been a real Stuart army in Britain, with real support from Jacobite aristocrats, and from at least part of the people. The replacement of the unknown fifty-five-year-old German who sat on the throne with the late Queen’s half-brother seemed perfectly plausible.

By 1736, it didn’t seem so anymore, or only to people like Robert Nixon and Samuel Killingbeck. After twenty years of Hanoverian stability, the Stuarts had receded several steps into the realm of myth. A French-speaking king didn’t seem any more desirable than a German-speaking one. And although he had ditched much of the baggage of absolutism, James Stuart had stubbornly refused to turn away from Rome. The world had moved on. The opposition had found some other ground on which to fight its battles.

Jacobitism had become something more diffuse; the king across the water was wreathed in mist. The mist was partly made up of romantic memories and partly of dreams for a better future. Nine years later, in 1745, when the mist briefly evaporated and a real Jacobite army was marching through England behind a real Stuart prince, the main emotion among English Jacobites was one of alarm. The Pretender didn’t realize it himself, but after twenty-one years Jacobitism in England had turned into something quite different from a campaign to restore him.

Instead, it had become a general form of protest against those in power. As long as there was Jacobitism, there was an alternative to the Hanoverians. Jacobitism became a way of withholding support. That way, the King of England and his ministers, like everyone else, had to live with uncertainty. It had metamorphosed into a general spirit of subversion. Disgruntled Tory squires toasted the ‘King over the Water’ to express their disenchantment with London, the times and Walpole’s ministry. Jacobite songs like ‘The King Shall Enjoy His Own Again’ became a way to cheek anyone in authority.

This has led me to think about the knee-jerk “oppositionism” that characterizes a lot of debate in the U.S. for past decade-plus. It also, as ever, puts me in mind of Orwell. From England, Your England (1941):

One rapid but fairly sure guide to the social atmosphere of a country is the parade-step of its army. A military parade is really a kind of ritual dance, something like a ballet, expressing a certain philosophy of life. The goose-step, for instance, is one of the most horrible sights in the world, far more terrifying than a dive-bomber. It is simply an affirmation of naked power; contained in it, quite consciously and intentionally, is the vision of a boot crashing down on a face. Its ugliness is part of its essence, for what it is saying is, ‘Yes, I am ugly, and you daren’t laugh at me,’ like the bully who makes faces at his victim. Why is the goose-step not used in England? There are, heaven knows, plenty of army officers who would be only too glad to introduce some such thing.

It is not used because the people in the street would laugh. Beyond a certain point, military display is only possible in countries where the common people dare not laugh at the army. The Italians adopted the goose-step at about the time when Italy passed definitely under German control, and, as one would expect, they do it less well than the Germans. The Vichy government, if it survives, is bound to introduce a stiffer parade-ground discipline into what is left of the French army. In the British army the drill is rigid and complicated, full of memories of the eighteenth century, but without definite swagger; the march is merely a formalized walk. It belongs to a society which is ruled by the sword, no doubt, but a sword which must never be taken out of the scabbard.

Go, Cabal!

According to this WashPost piece by Sebastian Mallaby, Paul Wolfowitz is doing a good job at revamping the World Bank’s policies regarding lending money to despotic regimes and graft-ridden contracts:

The new boss is going to be tough on corruption, and he’s going to push this campaign beyond the confines of the World Bank; on Saturday he persuaded the heads of several regional development banks to join his anti-corruption effort. It’s amusing to see the Wolfensohn-Stiglitz left-liberal critique of narrowly economic development policy being championed by this neoconservative icon; and it’s encouraging as well.

The Greatest and Most Natural Movement

Good article by Robert Hughes on Rembrandt, in honor of the 400th anniversary of the artist’s birth. It turns out that Hughes likes one of my least favorite R. paintings, The Polish Rider, which I saw at the Frick and was convinced was a joke.

Discussing the majesty of Peiro, Raphael and Poussin, he writes

But what you are not likely to feel is a sense of community with these magnificent products of human thought and imagination. Were there really people who looked like this, who could be seen walking the streets of Rome, Arezzo or Paris? Who could be spoken to, and answer your voice? It seems implausible. We look at them for quite different reasons. We admire their difference, and their distance, from us.

But then there are artists whose work is not like this. They are the ones who acknowledge human imperfection and mortality. And not only acknowledge it, but in some sense glory in it, making it the prime subject of their art. For if men and women were perfect, mentally, physically, morally, spiritually, why would they need art at all?

For that, we need Rembrandt. I’ve written about his paintings a few times in the three years I’ve been keeping my virtual memories (I missed my blogiversary a few weeks ago), but I’ve only done so tentatively. The best of it was probably in this Interminably Long Ramble.

If you’re going to be in Amsterdam in the next few months, you should check out the Rembrandt-Caravaggio exhibit that Hughes’ article is plugging.

If you’re a fine art aficionado and a NASCAR fan, check out the Rembrandt 400.

Before the flood

Just finished reading Rob Walker’s Letters from New Orleans, which I enjoyed much more than Tom Piazza’s Why New Orleans Matters. I found the latter to be far too preachy, bordering on a sort of “White Man’s Burden” for why no expense must be spared in rebuilding the city. Walker’s book, on the other hand, made me care much more for the city and what it means and has meant.

Maybe the big difference is that one writer was discussing NO,LA pre-Katrina, and the other post-Katrina.

Or maybe it’s that one writer is a journalist, and the other is a novelist.

Or maybe one guy is someone you could just chill out and have a beer with, and the other guy is a douche.