“Then the hostess’s dog attacked me, so I had to stab it.”

Evidently, the role of my GP is being played by Dr. Spaceman (“That’s spi-CHEM-in!”). While I was getting treated for a sinus infection earlier this week, my doctor looked over my file and asked, “We prescribed some Ambien for you on your last visit. How’s that working?”

I replied, “Pretty well, but sometimes it doesn’t do a thing, so I lie there unable to sleep and pissed off at Sanofi-Aventis.”

“Well, have you tried taking two at a time?” he asked.

“What? NO!” I replied.

He proceeded to tell me that taking two of the 6.25mg doses was “just like” taking one of the higher dose, 12.5mg.

Later, when he asked about drug allergies, I expected him to say, “What can you do? Medicine’s not a science!”

The most depressing job ever

One of the features in the October ish of my magazine is an interview with Dr. Robert Maguire, chief of operations for Wyeth’s R&D efforts. I finished laying out the section this morning, because I was waiting for the company to send over Dr. Maguire’s bio.

For any of you who think your job is a downer, Dr. Maguire’s first career should shut you up. Prior to working in the pharma industry, he was trained as a pediatric oncologist.

Try to imagine your spouse/partner working in that field, and then try to imagine asking, “How was work today?”

Radio Silence

I know it sounds like I’m always under a huge pile of work, dear readers, but this time I mean it. Last week’s conference overrode my other responsibilities, and now I have to finish a 156-page issue by Friday morning, so I can catch my flight to Milan in the afternoon to cover the CPhI/ICSE conference.

Yesterday, I finally believed that this was doable. Shortly after that, I got pasted with a cold.

Upshot: you likely won’t see any posts here till Friday morning’s Unrequired reading. Oh, and you’ll probably get to see a bunch of neat photos from Milan & environs next week.

Conference Call

We hosted our big (around 400+ people) pharma-conference & exhibition yesterday, and that’s the most nerve-wracking day of my year.

This edition’s Big Surprise occurred shortly before the first presentation, when our marketing assistant informed me that, while he did bring down the PC laptop that we use for the presentations, he forgot to bring the power supply for it. So I had to go through our exhibit hall, check out which of the 130 vendors happened to be using ThinkPads, and cajole use of their power-cords during the day.

We have 5 more presentations going on this morning, but the exhibition ended yesterday, so I’m not entirely sure how I’m going to manage to keep that laptop powered up.

From the Editor: Idiot’s Alchemy

(Sorry I haven’t written much lately, dear readers. I’ve been awfully busy at work, and pretty burned-out by the time I’m home. But I’ll wrap up most of it today, and then Amy & I are off on a mini-vacation. More later! Meanwhile, here’s this issue’s From the Editor column.)

Idiots’ Alchemy

Making money out of nothing at all

In keeping with last issue’s Hollywood-themed editorial, I’ve decided to write a sequel! This month, we move from blockbusters to bombs. In Hudson Hawk, my favorite terrible movie, the archvillains plot to demolish the world banking system by flooding it with alchemically produced gold. At least, I think that’s the plot. It’s tough to follow, what with the implausible action sequences, candy-bar code-named CIA operatives (with David Caruso as Kit Kat!), a nun-as-love-interest, and musical numbers featuring Danny Aiello and Bruce Willis.

The action revolves around Darwin and Minerva Mayflower — campily played by Richard E. Grant and Sandra Bernhard — and their reconstruction of a lead-to-gold machine designed by Leonardo Da Vinci. Says Minerva, “After a couple of years of steady production, we’ll flood the market with so much gold that gold itself — the foundation of all finance — will lose its meaning.”

Of course, Nixon ended the gold standard 20 years before Hudson Hawk came out, rendering the Mayflowers’ plot moot. And yet it’s also eerily prescient. After all, gold qua gold doesn’t mean so much anymore, not as a “foundation of all finance.” Now it’s just another commodity in which to invest.

What we’re left with is money itself. Funnily enough, while we’re free of gold, we haven’t gotten over alchemy. Instead of la machina oro, we have “quant funds,” those hedge funds that employ statistical models so sophisticated that they can “find winning trade strategies,” as the Wall Street Journal puts it. From equations to money, like magic!

Turns out one of these winning trade strategies was investing in financial instruments that were based heavily on subprime mortgages (that is, the practice of giving large loans to people who have poor credit). Some of these sophisticated investing models managed to underestimate the risk of — repeat after me — giving large loans to people who have poor credit.

Finding themselves pummeled by margin calls and investor redemption requests (that is, investors trying to get their money out of these fabulous funds before it all disappeared), some funds required massive bailouts from their parent institutions. Outspoken financial personality Jim Cramer made the YouTube rounds by ranting about how the government needs to step in with an interest reduction, ostensibly to save the homes of subprime mortgage holders, but also to save the jobs of hedge fund managers.

Evaluating risk — the true foundation of finance — lost its meaning. For a while.

So how does this tie into pharma? Well, first there’s the direct impact of this credit shakeup on private equity firms. Many of these groups employ leveraging techniques to (partially) fund acquisitions of public companies. We’ve seen several contract manufacturers acquired by PE firms this year, but with money less easy to borrow, will further acquisitions be back-burnered?

But the other pharma tie-in is potentially more damaging, and that’s the bizarre talk about a new round of mega-mergers in the drug industry. First we heard rumors of Novartis’ interest in buying Bayer, and then an analyst floated the idea that Pfizer should acquire Wyeth.

Regarding the former, you can learn more with Derek Lowe’s In the Pipeline excerpt on page 40. As far as the latter? Well, I think the argument for a Pfizer/Wyeth hookup is far more flawed than that which guided Pfizer’s Warner-Lambert and Pharmacia buys earlier this decade. In those instances, Pfizer could point to its co-marketing agreements for major drugs and show how 100% control of those products would lead to greater sales. You may recall that I disagreed with those moves, not that I take any joy in how that turned out.

Now? Pfizer’s key motivation (says our analyst) is the acquisition of Wyeth’s biologics program, which she compares to AstraZeneca’s MedImmune acquisition. Which cost more than a dozen times MedImmune’s earnings. In cash.

But I’m starting to think that the point of these rumors — and there’ll be more this year — isn’t to push for those particular mergers. Rather, it’s to incite any sort of big merger activity, because the banks that took a bath this summer need to boost their financing and underwriting businesses this fall.

Let’s hope the new CFOs are smart enough to keep the industry’s recent merger history in mind. Otherwise, we could be looking more upheaval. Or, as Darwin Mayflower put it in Hudson Hawk, “History, tradition, culture: these are not concepts! These are trophies I keep in my den as paperweights! The chaos we cause the world with this machine will be our final masterpiece! Go, team, go!”

It also fixes your schwerve

Sure, I get plenty of headaches at work, but there’s also fun to be had. You just have to know where to look. For instance, while checking out news releases this morning, I stumbled across a clinical-stage drug that’s described as a “minor groove binder.”

Physical Humor

I’m in my mid-30s and have a family history of high blood pressure, diabetes and heart disease, so I figure it’s best that I start getting some expert opinion on my health. I’m not diligent enough to see a doctor regularly, but I did manage to have my nowhere-near-annual physical this morning.

I had to fill out a general medical info form when I got to the office. Near the top of the form was a line for ‘Chief complaint,’ which I responded to with “high taxes.” I know I should’ve gone with “incivility on the internet,” but that’s what you get for writing in ink.

Anyway, the doctor was happy with pretty much everydarnthing. My LDL’s a little high, but it’s down 30 points from my last checkup in September 2005, so no statins for me! Blood pressure, heart-rate and EKG were also just fine. He even praised my moderate drinking, though he admitted that there wasn’t a ton of research on the benefits of gin.

I was actually a little worried about that EKG, given a family member’s recent episode of SVT, but the doctor assuaged my fears on that one. He mentioned that the EKG showed no basic signs of it and, “When you hit 50, we’ll do a stress test and all the other regular exams.”

“When I’m 50,” I said, “we’ll have nanobots to take care of that stuff.”

Then I thought, I’m gonna be 50?

Lay it down

Today’s WSJ has an interview with GlaxoSmithKline CEO Jean-Pierre Garnier. While the bulk of the interview covers the company’s Avandia crisis, JP also kicks some wisdom regarding the “developing world”:

WSJ: Glaxo recently donated 50 million pandemic flu vaccines to the World Heath Organization. What’s the story?

Dr. Garnier: It’s probably the largest vaccine donation ever. The company could have sold possibly those 50 million units. They [Glaxo] decided to set them aside because frankly those countries are not going to buy any pandemic vaccine. Some of them have no commitment to health care.

Let’s call a cat a cat. They’ll buy a lot of other things including Kalashnikovs before they allocate enough money for health care in their own countries.